Accutane, or isotretinoin, powerfully reduces sebum production. This is key, because excess sebum fuels acne. It achieves this by binding to retinoic acid receptors in sebaceous glands, significantly slowing oil production.
Beyond sebum reduction, Accutane also affects the growth and structure of skin cells. It shrinks the size of sebaceous glands, further limiting oil output. This also reduces the likelihood of clogged pores, a major factor in acne development. Additionally, it impacts inflammation, a crucial component of acne lesions. Accutane modulates inflammatory pathways, helping to diminish redness and swelling.
However, these powerful effects can have side effects. The impact on sebum production can sometimes extend to hair follicles. Because hair health partly relies on oil production, a reduction can lead to hair thinning or dryness in some individuals.
| Sebum Reduction | Binds to retinoic acid receptors in sebaceous glands | Dryness, thinning |
| Sebaceous Gland Size Reduction | Alters growth and structure of sebaceous glands | Reduced oil for hair follicles |
| Inflammation Modulation | Impacts inflammatory pathways | Indirect influence, potentially positive or negative |
Individual responses vary considerably. While Accutane can cause hair thinning for some, others experience no such effect. Consulting a dermatologist is paramount to assess your individual risk factors and discuss potential solutions.
