Monitor patients closely for signs of prolonged QT interval, especially those with pre-existing cardiac conditions or taking medications that prolong the QT interval. Report any changes in heart rhythm immediately.
Headache is a common side effect. Encourage patients to drink plenty of fluids and consider recommending over-the-counter pain relief, such as acetaminophen, unless contraindicated.
For constipation, advise patients to increase fluid and fiber intake. Suggest gentle exercise. If constipation persists, consult a physician regarding appropriate treatment options.
Managing Severe Reactions
Severe allergic reactions, such as anaphylaxis, require immediate medical attention. Administer epinephrine and other supportive measures as needed. Transfer to a higher level of care immediately. Document all actions taken.
Understanding and Addressing Other Side Effects
Drowsiness is possible. Caution patients against operating heavy machinery or driving until they know how Zofran affects them. Other reported side effects include dizziness and fatigue. Patient education focusing on symptom management and safety is critical.
| Prolonged QT Interval | Cardiac monitoring, immediate reporting of changes |
| Headache | Hydration, acetaminophen (if appropriate) |
| Constipation | Increased fluid and fiber, exercise, physician consultation if needed |
| Allergic Reaction | Epinephrine, supportive care, transfer to higher level of care |
| Drowsiness/Dizziness/Fatigue | Patient education on safety precautions |
