Prednisone can interact with many medications, potentially altering their effectiveness or increasing side effects. Always inform your doctor and pharmacist about all medications, supplements, and herbal remedies you’re taking, including over-the-counter drugs.
Here are some key drug interactions to be aware of:
| Nonsteroidal Anti-inflammatory Drugs (NSAIDs) | Ibuprofen, naproxen, aspirin | Increased risk of stomach ulcers and bleeding. |
| Blood thinners (anticoagulants) | Warfarin, heparin | Increased risk of bleeding. Close monitoring of blood clotting is necessary. |
| Diabetes medications | Insulin, oral hypoglycemics | Prednisone can raise blood sugar levels, requiring dose adjustments of diabetes medications. |
| Potassium-depleting diuretics | Hydrochlorothiazide, furosemide | Increased risk of potassium deficiency (hypokalemia). Regular potassium level checks are recommended. |
| Digoxin | Digoxin | Prednisone can increase the levels of digoxin in the blood, leading to toxicity. Close monitoring of digoxin levels is crucial. |
| Immunosuppressants | Cyclosporine, tacrolimus | Increased risk of infections and other side effects. Careful monitoring is required. |
| Live vaccines | Measles, mumps, rubella, chickenpox | Prednisone can suppress the immune system, rendering live vaccines ineffective or even dangerous. Avoid live vaccines while on prednisone. |
This table isn’t exhaustive; other interactions are possible. Consult your healthcare provider for personalized advice regarding potential drug interactions with your specific medications and medical history. They can help you manage your medications safely and effectively.
