Sildenafil targets a specific enzyme called phosphodiesterase-5 (PDE5). PDE5 breaks down cyclic guanosine monophosphate (cGMP), a crucial molecule for achieving and maintaining an erection.
By inhibiting PDE5, sildenafil allows cGMP levels to rise. Increased cGMP relaxes the smooth muscles in the blood vessels of the penis, leading to increased blood flow. This engorgement of blood is what produces an erection.
This process requires sexual stimulation. Sildenafil doesn’t directly cause erections; it simply enhances the body’s natural response to sexual stimulation.
Importantly, the effects are temporary and typically last several hours. The body naturally breaks down sildenafil, and cGMP levels return to normal, ending the vasodilation.
Note: Individual responses to sildenafil vary, and factors like age, overall health, and other medications can influence its effectiveness.
