Augmentin-induced kidney damage rarely presents with dramatic symptoms. Instead, subtle changes in kidney function often precede noticeable issues. Monitor for decreased urine output (oliguria), changes in urine color (darker urine may indicate problems), or swelling in the legs, ankles, or feet (edema), all suggestive of fluid retention. These symptoms, though non-specific, warrant prompt medical attention.
Laboratory Findings
Blood tests revealing elevated creatinine and blood urea nitrogen (BUN) levels are key indicators of kidney impairment. These reflect reduced kidney filtration capacity. Furthermore, monitor for changes in electrolytes, particularly potassium, as kidney dysfunction impacts their balance. Urine analysis might show proteinuria (protein in the urine) or hematuria (blood in the urine), further supporting the diagnosis. A decrease in glomerular filtration rate (GFR), assessed using serum creatinine and other factors, confirms a reduction in kidney function.
Diagnostic Procedures
Ultrasound scans can help visualize kidney structure, identifying any size or shape abnormalities that might indicate underlying kidney disease. In complex cases, a kidney biopsy provides the most definitive diagnosis and can identify the specific type of kidney injury. This procedure helps differentiate Augmentin-related injury from other causes. Closely monitor serum creatinine levels throughout the course of Augmentin therapy, ensuring early detection of any adverse effects.
