Cialis, or tadalafil, primarily works by inhibiting phosphodiesterase-5 (PDE5). This enzyme breaks down cyclic guanosine monophosphate (cGMP), a molecule crucial for smooth muscle relaxation. By blocking PDE5, Cialis increases cGMP levels, leading to vasodilation, particularly in the blood vessels of the penis, improving erectile function.
Impact on Intraocular Pressure
Studies investigating Cialis’s effect on intraocular pressure (IOP) have yielded mixed results. Some research suggests a slight, temporary increase in IOP, while others show no significant change. The magnitude of any IOP alteration appears modest and typically within the normal physiological range. However, individuals with pre-existing glaucoma or other conditions affecting IOP should discuss potential risks with their ophthalmologist before using Cialis. Close monitoring of IOP might be advisable for these patients.
Factors Influencing IOP Changes
Several factors can influence Cialis’s impact on IOP, including dosage, individual patient factors, and concurrent medications. Higher doses of Cialis may be associated with a slightly greater potential for IOP elevation. Additionally, patients with compromised hepatic or renal function might experience altered drug metabolism, influencing IOP responses. Patients should always disclose all medications they are taking to their doctor and ophthalmologist.
