Viagra, or sildenafil, works primarily by inhibiting an enzyme called phosphodiesterase-5 (PDE5). This enzyme breaks down cyclic guanosine monophosphate (cGMP), a crucial molecule for achieving and maintaining an erection.
Here’s a simplified breakdown:
Sexual stimulation triggers the release of nitric oxide (NO). NO activates an enzyme called guanylate cyclase. Guanylate cyclase increases cGMP levels. Increased cGMP relaxes the smooth muscles in the blood vessels of the penis. This relaxation allows increased blood flow into the penis, leading to an erection. PDE5 normally breaks down cGMP, reducing blood flow. Viagra blocks PDE5. By blocking PDE5, Viagra prolongs the effects of cGMP, maintaining increased blood flow and facilitating an erection.
Consequently, Viagra enhances the body’s natural response to sexual stimulation. It doesn’t directly cause an erection; it facilitates the process initiated by sexual arousal.
- Remember, Viagra’s effects depend on sexual stimulation. It’s crucial to consult a doctor before use, to discuss potential side effects and drug interactions.
