Naproxen reduces pain and inflammation by inhibiting the production of prostaglandins.
Cyclooxygenase Inhibition
Specifically, naproxen targets cyclooxygenase (COX) enzymes, COX-1 and COX-2. These enzymes are responsible for converting arachidonic acid into prostaglandins. Prostaglandins mediate pain signaling and contribute to inflammation. By blocking COX enzymes, naproxen reduces prostaglandin synthesis, thus alleviating pain and inflammation.
COX-1 and COX-2 Selectivity
While naproxen isn’t as selective for COX-2 as some newer NSAIDs, it still exhibits a preference for COX-2 inhibition at therapeutic doses. This selectivity helps to minimize some of the gastrointestinal side effects associated with non-selective COX inhibition.
Effects on the Body
- Pain Relief: Naproxen effectively reduces pain by blocking the production of prostaglandins that sensitize pain receptors. Anti-inflammatory Action: The reduction in prostaglandins also lessens inflammation, swelling, and redness. Fever Reduction: Naproxen can lower fever by affecting the hypothalamus, the body’s temperature regulation center.
Important Considerations
Naproxen can interact with other medications. Always consult a doctor or pharmacist before taking naproxen concurrently with other drugs, especially blood thinners, anticoagulants, or other NSAIDs. Gastrointestinal issues, like upset stomach or ulcers, are potential side effects. Taking naproxen with food can often help mitigate these. Dosage should be carefully followed. Exceeding the recommended dose increases the risk of side effects.
Further Research
For more detailed information on naproxen, consult reliable medical resources such as your doctor, pharmacist, or reputable medical websites.
