Prednisone, a corticosteroid, can interfere with your blood’s ability to clot. It does this by decreasing the production of certain clotting factors, leading to a higher risk of bleeding.
INR Monitoring
If you’re on blood thinners like warfarin (Coumadin), monitoring your International Normalized Ratio (INR) is crucial while taking prednisone. Prednisone can alter your INR, potentially making you either more or less prone to bleeding. Your doctor needs to carefully monitor your INR and adjust your warfarin dosage as needed. Frequent blood tests are expected.
Increased Bleeding Risk
Prednisone increases your risk of bleeding, even without warfarin. Be mindful of this risk. Avoid activities that increase your risk of injury. Report any unusual bleeding, such as nosebleeds, heavy menstrual periods, or easy bruising to your healthcare provider immediately.
Other Medications
Interactions with other medications are possible. Always inform your doctor and pharmacist of all medications, including over-the-counter drugs and supplements, you are taking. This ensures they can assess potential risks and interactions.
Managing the Risk
Careful monitoring and open communication with your doctor are key to safely managing the effects of prednisone on your blood clotting. They can provide tailored advice and help you minimize risks. Remember to report any concerns promptly.


