Always inform your doctor about all medications you’re taking, including over-the-counter drugs, supplements, and herbal remedies, before starting tadalafil. This is particularly important with 40 mg, a higher dose than typically prescribed.
Nitrates and Tadalafil: A Dangerous Combination
Combining tadalafil with nitrates (found in some heart medications) can cause a dangerous drop in blood pressure, potentially leading to fainting or a heart attack. This interaction is serious and should be strictly avoided. Discuss alternative treatments with your doctor if you use nitrates.
Alpha-blockers and Tadalafil: Potential for Low Blood Pressure
Concomitant use of tadalafil and alpha-blockers (prescribed for high blood pressure or prostate problems) may increase the risk of low blood pressure, especially during the initial days of treatment. Your doctor may adjust your dosages or suggest alternative medications to minimize this risk.
CYP3A4 Inhibitors and Tadalafil: Increased Tadalafil Levels
Medications that inhibit the CYP3A4 enzyme (like ketoconazole, erythromycin, and some HIV medications) can increase tadalafil levels in your blood, potentially leading to increased side effects. Your doctor may need to adjust your tadalafil dose or prescribe an alternative.
Grapefruit Juice and Tadalafil: A Cautionary Note
Grapefruit juice also inhibits CYP3A4 and can interact similarly to other CYP3A4 inhibitors, increasing tadalafil blood levels and the risk of side effects. Limit or avoid grapefruit juice consumption while taking tadalafil.
This information is not exhaustive. Individual responses to drug interactions can vary. Always consult your doctor or pharmacist for personalized advice on managing potential interactions with your specific medications and health conditions.
