Begin with a low infusion rate, typically 2 mg/min, and carefully monitor blood pressure and heart rate. Adjustments should be made incrementally based on the patient’s response.
For patients with bradycardia (heart rate below 60 bpm), reduce the infusion rate or temporarily halt the infusion. Closely monitor heart rate and rhythm. Consider alternative antihypertensive agents if necessary.
In cases of hypotension (systolic blood pressure below 90 mmHg), immediately decrease the infusion rate or stop the infusion completely. Monitor blood pressure frequently and support circulation as needed.
- Hypotension management might involve fluid resuscitation with intravenous fluids (isotonic solutions) and/or supportive measures, depending on the severity of hypotension and patient’s underlying conditions. If significant hypotension occurs despite slowing or halting the labetalol infusion, consider administering vasopressors as clinically indicated.
Patients with asthma or chronic obstructive pulmonary disease (COPD) may require careful titration due to potential bronchospasm. Monitor respiratory rate and oxygen saturation closely. Lower infusion rates might be warranted.
For patients with hepatic or renal impairment, a reduced infusion rate and more cautious titration are recommended. Consider labetalol’s clearance and half-life adjustments in these patients.
Reduce the initial infusion rate. Extend the intervals between titration adjustments. Closely observe for adverse effects, paying particular attention to the patient’s blood pressure, heart rate, and renal function.
Elderly patients may be more sensitive to labetalol’s effects. Start with lower infusion rates and titrate cautiously to prevent excessive hypotension.
Always prioritize continuous monitoring of vital signs, including blood pressure, heart rate, and respiratory rate. Document all adjustments and the patient’s response to the infusion.
